The Meharry Microarray and Bioinformatics Core (MMBC) provides state of the art training, instrumentation, services and bioinformatics-driven data analysis to the Meharry Community in microarray experimental design, manipulation, and gene expression analysis.
We also aid investigators and trainees in validation of microarray results using RNA QA/QC and real time PCR results.
Finally, this Core Resource aids Meharry investigators and trainees with high performance computation in proteomics as well as genomics. Gene and protein pathways analysis and shotgun proteomics (mass spectrometry) analysis are just two more of the services that we provide.
It is our aim to keep this facility up to date computationally and intellectually with state of the art “Omics” services to support education and research in microarray, genomics and proteomics data analysis, computational biology, and systems biology.
"The Agilent 2100 Bioanalyzer is a microfluidics-based platform for sizing, quantification and quality control of DNA, RNA, proteins and cells on a single platform. Results are delivered within 30-40 minutes in automated, high quality digital data."
"Whenever possible, data analysis is approached as a training opportunity. However, there are times when this is undesirable either due to the complexity of the data (and analysis options) or the wishes of the investigator. In these instances, we do perform data analysis but request the participation of the investigator (particularly in the case of microarray data) as a fundamental understanding of the biology and experiment that can only be supplied by the person who has done the work is required for an appropriate analysis."
Experiment design and data analysis for Gene transcription microarray experiments.
"Cytoscape is an open source bioinformatics software platform for visualizing molecular interaction networks and biological pathways and integrating these networks with annotations, gene expression profiles and other state data." Systems biology analysis software. Uses Java.
"MATLAB® is a high-level language and interactive environment that enables you to perform computationally intensive tasks faster than with traditional programming languages such as C, C++, and Fortran."